STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
toxSRegulatory protein ToxS; Interacts with ToxR and stimulates its activity. (173 aa)    
Predicted Functional Partners:
toxR
Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
    
 0.994
tcpP
Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis.
    
 0.897
VC_0982
Selenoprotein W-related protein; Similar to SP:O19097; identified by sequence similarity; putative.
       0.687
htpG
Heat shock protein HtpG; Molecular chaperone. Has ATPase activity; Belongs to the heat shock protein 90 family.
     
 0.635
tcpH
Toxin co-regulated pilus biosynthesis protein H; Involved in TCP pilus biogenesis.
      
 0.542
tcpN
TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon.
      
 0.542
VC_0278
Transcriptional activator CadC, putative; Similar to SP:P23890 GB:M67452 PID:145452 PID:536978 GB:U00096; identified by sequence similarity; putative.
    
 0.525
ompU
Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane.
      
 0.479
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.