| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VC_0982 | toxR | VC_0982 | VC_0984 | Selenoprotein W-related protein; Similar to SP:O19097; identified by sequence similarity; putative. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.792 |
| VC_0982 | toxS | VC_0982 | VC_0983 | Selenoprotein W-related protein; Similar to SP:O19097; identified by sequence similarity; putative. | Regulatory protein ToxS; Interacts with ToxR and stimulates its activity. | 0.792 |
| ctxA | ompU | VC_1457 | VC_0633 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | 0.559 |
| ctxA | tcpN | VC_1457 | VC_0838 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.753 |
| ctxA | tcpP | VC_1457 | VC_0826 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis. | 0.425 |
| ctxA | toxR | VC_1457 | VC_0984 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.845 |
| ompU | ctxA | VC_0633 | VC_1457 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.559 |
| ompU | tcpN | VC_0633 | VC_0838 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.498 |
| ompU | tcpP | VC_0633 | VC_0826 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis. | 0.476 |
| ompU | toxR | VC_0633 | VC_0984 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.984 |
| ompU | toxS | VC_0633 | VC_0983 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Regulatory protein ToxS; Interacts with ToxR and stimulates its activity. | 0.752 |
| rpoA | rpoB | VC_2571 | VC_0328 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoA | rpoC | VC_2571 | VC_0329 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoA | rpoD | VC_2571 | VC_0517 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.998 |
| rpoA | tcpN | VC_2571 | VC_0838 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.630 |
| rpoA | tcpP | VC_2571 | VC_0826 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis. | 0.902 |
| rpoA | toxR | VC_2571 | VC_0984 | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.947 |
| rpoB | rpoA | VC_0328 | VC_2571 | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoB | rpoC | VC_0328 | VC_0329 | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.999 |
| rpoB | rpoD | VC_0328 | VC_0517 | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.999 |
