Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VC_0982 | toxR | VC_0982 | VC_0984 | Selenoprotein W-related protein; Similar to SP:O19097; identified by sequence similarity; putative. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.686 |
| VC_0982 | toxS | VC_0982 | VC_0983 | Selenoprotein W-related protein; Similar to SP:O19097; identified by sequence similarity; putative. | Regulatory protein ToxS; Interacts with ToxR and stimulates its activity. | 0.687 |
| VC_1363 | tcpP | VC_1363 | VC_0826 | Siroheme synthase component enzyme; Similar to PID:576655; identified by sequence similarity; putative. | Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis. | 0.467 |
| VC_1363 | toxR | VC_1363 | VC_0984 | Siroheme synthase component enzyme; Similar to PID:576655; identified by sequence similarity; putative. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.558 |
| ctxA | ompU | VC_1457 | VC_0633 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | 0.487 |
| ctxA | tcpA | VC_1457 | VC_0828 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | 0.613 |
| ctxA | tcpN | VC_1457 | VC_0838 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.509 |
| ctxA | toxR | VC_1457 | VC_0984 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.746 |
| ctxA | zot | VC_1457 | VC_1458 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Zona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). | 0.808 |
| ompU | ctxA | VC_0633 | VC_1457 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.487 |
| ompU | tcpA | VC_0633 | VC_0828 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | 0.502 |
| ompU | tcpN | VC_0633 | VC_0838 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.432 |
| ompU | tcpP | VC_0633 | VC_0826 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Toxin co-regulated pilus biosynthesis protein P; Involved in TCP pilus biogenesis. | 0.418 |
| ompU | toxR | VC_0633 | VC_0984 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | 0.784 |
| ompU | toxS | VC_0633 | VC_0983 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Regulatory protein ToxS; Interacts with ToxR and stimulates its activity. | 0.479 |
| ompU | zot | VC_0633 | VC_1458 | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | Zona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). | 0.448 |
| tcpA | ctxA | VC_0828 | VC_1457 | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.613 |
| tcpA | ompU | VC_0828 | VC_0633 | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane. | 0.502 |
| tcpA | tcpH | VC_0828 | VC_0827 | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | Toxin co-regulated pilus biosynthesis protein H; Involved in TCP pilus biogenesis. | 0.608 |
| tcpA | tcpN | VC_0828 | VC_0838 | Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium. | TCP pilus virulence regulatory protein; Probable regulatory protein for the tcp operon. | 0.720 |
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