| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| VC_2067 | luxO | VC_2067 | VC_1021 | MinD-related protein; Similar to GP:3695013; identified by sequence similarity; putative. | LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes. | 0.770 |
| VC_2529 | VC_2748 | VC_2529 | VC_2748 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | 0.557 |
| VC_2529 | hfq | VC_2529 | VC_0347 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Host factor-I, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Essential for virulence in the suckling mouse model of cholera pathogenesis; Belongs to the Hfq family. | 0.784 |
| VC_2529 | luxO | VC_2529 | VC_1021 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes. | 0.900 |
| VC_2529 | luxS | VC_2529 | VC_0557 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.646 |
| VC_2529 | luxU | VC_2529 | VC_1022 | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Phosphorelay protein; Phosphorelay protein which receives sensory signals from a sensory kinase and transmit them to LuxO. At low cell density, a phosphoryl group is transferred from the sensory kinase, probably on His-57 and this phosphoryl group is further transferred to LuxO. | 0.561 |
| VC_2748 | VC_2529 | VC_2748 | VC_2529 | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.557 |
| VC_2748 | cqsS | VC_2748 | VC_A0522 | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. | 0.434 |
| VC_2748 | luxO | VC_2748 | VC_1021 | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes. | 0.783 |
| VC_2748 | luxQ | VC_2748 | VC_A0736 | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | Sensor histidine kinase LuxQ; At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity). | 0.445 |
| cqsA | cqsS | VC_A0523 | VC_A0522 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. | 0.988 |
| cqsA | hfq | VC_A0523 | VC_0347 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Host factor-I, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Essential for virulence in the suckling mouse model of cholera pathogenesis; Belongs to the Hfq family. | 0.696 |
| cqsA | luxO | VC_A0523 | VC_1021 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes. | 0.816 |
| cqsA | luxP | VC_A0523 | VC_A0737 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | luxP protein; Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro- [2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein (By similarity). | 0.806 |
| cqsA | luxQ | VC_A0523 | VC_A0736 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Sensor histidine kinase LuxQ; At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity). | 0.839 |
| cqsA | luxS | VC_A0523 | VC_0557 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.842 |
| cqsA | luxU | VC_A0523 | VC_1022 | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | Phosphorelay protein; Phosphorelay protein which receives sensory signals from a sensory kinase and transmit them to LuxO. At low cell density, a phosphoryl group is transferred from the sensory kinase, probably on His-57 and this phosphoryl group is further transferred to LuxO. | 0.801 |
| cqsS | VC_2748 | VC_A0522 | VC_2748 | Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. | Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. | 0.434 |
| cqsS | cqsA | VC_A0522 | VC_A0523 | Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. | Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. | 0.988 |
| cqsS | hfq | VC_A0522 | VC_0347 | Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO. | Host factor-I, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Essential for virulence in the suckling mouse model of cholera pathogenesis; Belongs to the Hfq family. | 0.720 |
