Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
luxUPhosphorelay protein; Phosphorelay protein which receives sensory signals from a sensory kinase and transmit them to LuxO. At low cell density, a phosphoryl group is transferred from the sensory kinase, probably on His-57 and this phosphoryl group is further transferred to LuxO. (113 aa)    
Predicted Functional Partners:
luxO
LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes.
  
 
 0.997
cqsS
Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO.
  
 0.995
luxQ
Sensor histidine kinase LuxQ; At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity).
  
 0.993
luxP
luxP protein; Binds to the signaling molecule autoinducer 2 (AI-2), a furanosyl borate diester, (3a-methyl-5,6-dihydrofuro- [2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts with the LuxQ sensor protein (By similarity).
     
 0.983
luxS
Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
      
 0.803
cqsA
Aminotransferase, class II; Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
     
 0.801
VC_2369
Sensor histidine kinase FexB; Similar to SP:P22763 GB:X53315 PID:40951 PID:606149 GB:U00096; identified by sequence similarity; putative.
  
 
 0.769
hfq
Host factor-I, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity). Essential for virulence in the suckling mouse model of cholera pathogenesis; Belongs to the Hfq family.
      
 0.766
VC_0303
Sensor histidine kinase; Similar to GP:2808665; identified by sequence similarity; putative.
  
 
 0.711
VC_1349
Sensory box sensor histidine kinase/response regulator; Similar to PID:1653075; identified by sequence similarity; putative.
  
 
 0.669
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.