Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa)    
Predicted Functional Partners:
VC_1126
Adenylosuccinate lyase; Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096; identified by sequence similarity; putative; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.986
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345; identified by sequence similarity; putative.
  
 0.966
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
 0.953
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.923
deoD1
Purine nucleoside phosphorylase; Similar to PID:1732037; identified by sequence similarity; putative.
    
 0.910
deoD2
Purine nucleoside phosphorylase; Similar to GB:U14003 SP:P09743 GB:M60917 PID:147309 PID:537224; identified by sequence similarity; putative.
    
 0.910
VC_0899
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
 0.907
VC_0710
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the multicopper oxidase YfiH/RL5 family.
    
  0.906
nutA
UDP-sugar hydrolase; Degradation of extracellular 5'-nucleotides for nutritional needs.
    
 0.906
VC_A0545
5`-nucleotidase, putative; Similar to GB:AE000520; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
    
 0.906
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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