STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_1064Lipoprotein-related protein; Similar to GB:U00096 SP:P77717 PID:1773137 PID:1786658; identified by sequence similarity; putative. (143 aa)    
Predicted Functional Partners:
VC_0047
Conserved hypothetical protein; Identified by Glimmer2; putative.
   
  
 0.651
VC_2166
Trp repressor-binding protein; Similar to GB:M99166 SP:P30849 PID:148264 GB:U00096 PID:1651499; identified by sequence similarity; putative.
   
  
 0.644
VC_1063
acyl-CoA thioesterase II; Similar to GB:M63308 SP:P23911 PID:147932 GB:U00096 PID:1773136; identified by sequence similarity; putative.
       0.579
gyrA
DNA gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.519
parC
Topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
  
  
 0.519
VC_0578
Hemolysin, putative; Similar to GB:S57691 SP:P46028 PID:299398; identified by sequence similarity; putative.
   
  
 0.477
VC_A0330
Hypothetical protein; Identified by Glimmer2; putative.
  
    0.415
VC_A1006
Organic hydroperoxide resistance protein, putative; Similar to GP:3098342; identified by sequence similarity; putative.
  
    0.415
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.