Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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rluEPseudouridine synthase family 1 protein; Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (290 aa)    
Predicted Functional Partners:
VC_1141
Isocitrate dehydrogenase; Similar to PID:1030696; identified by sequence similarity; putative; Belongs to the monomeric-type IDH family.
       0.736
der
GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
  
 0.722
VC_1860
Exodeoxyribonuclease III; Similar to PID:1388153; identified by sequence similarity; putative.
  
    0.698
cmk
Cytidylate kinase; Similar to SP:P23863 PID:42839 GB:U00096 PID:1651431 PID:1651438; identified by sequence similarity; putative.
 
  
 0.691
rlmL
Conserved hypothetical protein; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.
  
 
 0.661
truC
Pseudouridine synthase Rlu family protein; Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs; Belongs to the pseudouridine synthase RluA family.
 
 
 0.580
rplC
Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
   
 
 0.561
rluB
Pseudouridine synthase family 1 protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.
 
 
 
0.531
rplD
Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). As the V.cholerae S10 leader can be regulated in vitro by the E.coli L4 protein this suggests the endogenous protein controls its own S10 operon in a similar fashion.
  
 
 0.525
VC_A0010
Conserved hypothetical protein; Identified by Glimmer2; putative.
    
 
 0.521
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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