STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prpBCarboxyphosphonoenolpyruvate phosphonomutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. (308 aa)    
Predicted Functional Partners:
VC_1337
Methylcitrate synthase; Similar to GB:U00096 PID:1657529 PID:1786527; identified by sequence similarity; putative; Belongs to the citrate synthase family.
 
 0.989
VC_1338
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.947
VC_1335
Transcriptional regulator, GntR family; Similar to GB:U00096 PID:1787821; identified by sequence similarity; putative.
 
  
 0.929
VC_2092
Citrate synthase; Similar to GB:J01619 SP:P00891 GB:M28987 GB:M28988 GB:V01501; identified by sequence similarity; putative; Belongs to the citrate synthase family.
 
 0.921
VC_1339
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.903
VC_A0957
Malate synthase-related protein; Similar to SP:P37330 GB:X74547 PID:517247 PID:882505 GB:U00096; identified by sequence similarity; putative.
  
 
 0.853
VC_2033
Alcohol dehydrogenase/acetaldehyde dehydrogenase; Similar to GB:M33504 SP:P17547 GB:X59263 GB:X67326 PID:145206; identified by sequence similarity; putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.848
acsA
acetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.844
VC_1340
prpE protein; Similar to GB:U00096 SP:P77495 PID:1657531 PID:1786529; identified by sequence similarity; putative.
 
 
 0.840
VC_0734
Malate synthase A; Similar to SP:P08997 GB:X12431 PID:396349 PID:40887 GB:U00096; identified by sequence similarity; putative; Belongs to the malate synthase family.
   
 
 0.817
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.