Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_1350Antioxidant, putative; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (157 aa)    
Predicted Functional Partners:
VC_0186
Glutathione reductase; Similar to SP:P06715 GB:M13141 PID:146248 PID:466637 GB:U00096; identified by sequence similarity; putative.
 
  
 0.928
VC_2637
Peroxiredoxin family protein/glutaredoxin; Similar to GB:L42023 PID:1004026 PID:1222510 PID:1204821 SP:P44758; identified by sequence similarity; putative.
  
 
0.911
gshB
Glutathione synthetase; Similar to SP:P04425 GB:X01666 PID:41625 PID:882476 GB:U00096; identified by sequence similarity; putative.
     
 0.902
VC_0194
Gamma-glutamyltranspeptidase; Similar to GB:AL123456; identified by sequence similarity; putative.
     
  0.900
VC_0731
Antioxidant, AhpC/Tsa family; Similar to PID:965473; identified by sequence similarity; putative.
   
 0.871
dsbE
Thiol:disulfide interchange protein DsbE; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
   
 0.745
VC_1583
Superoxide dismutase, Cu-Zn; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.
   
 
 0.729
VC_1057
Proteinase inhibitor, putative; Similar to GB:U73004 SP:P97430 PID:1763263 PID:1945383 PID:1945451; identified by sequence similarity; putative; Belongs to the UPF0153 family.
   
   0.691
VC_2308
4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme; Similar to PID:1100872 GB:U00096 SP:Q46948 PID:1773108 PID:1786626; identified by sequence similarity; putative.
   
   0.691
VC_0306
Thioredoxin; Similar to SP:P00274 GB:M87049 GB:K02845 GB:M10424 GB:M12779; identified by sequence similarity; putative; Belongs to the thioredoxin family.
   
 
 0.650
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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