STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
vgrG1vgrG protein; Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of ano [...] (1163 aa)    
Predicted Functional Partners:
VC_1415
Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative.
 
  
 0.955
VC_A0111
Hypothetical protein; Identified by Glimmer2; putative.
 
 
 0.946
VC_A0107
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.938
VC_A0017
Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative.
 
  
 0.914
VC_A0115
Hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.897
VC_A0108
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.894
VC_A0109
Hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.894
VC_A0119
Hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.876
tseL
Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic as well as eukaryotic target cells.
     
 0.872
VC_A0110
Hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.870
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.