STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tseLHypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic as well as eukaryotic target cells. (641 aa)    
Predicted Functional Partners:
vgrG3
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus. Toxicity is counteracted by a cognate immunity protein TsiV3.
     
 0.895
tsiV1
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin TseL.
     
 0.880
vgrG1
vgrG protein; Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of ano [...]
     
 0.872
VC_1417
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.836
VC_1415
Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative.
     
 0.635
vgrG2
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co- regulated protein Hcp. Allows the delivery of the VasX antibacterial toxin to target cells where it exerts its toxicity.
     
 0.611
vasX
Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells.
      
 0.580
hlyC
Lactonizing lipase; Catalyzes the hydrolysis of triacylglycerol. Belongs to the AB hydrolase superfamily. Pseudomonas lipase family.
  
  
 0.573
tsiV3
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VgrG3.
      
 0.491
VC_1420
Hypothetical protein; Identified by Glimmer2; putative.
       0.480
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.