Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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fnrFumarate and nitrate reduction regulatory protein; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity). (250 aa)    
Predicted Functional Partners:
VC_1433
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
  
 0.837
VC_1436
FixS-related protein; Similar to PID:2398785; identified by sequence similarity; putative.
  
  
 0.754
VC_1437
Cation transport ATPase, E1-E2 family; Similar to PID:1200219; identified by sequence similarity; putative.
     
 0.752
VC_1442
Cytochrome c oxidase, subunit CcoN; Similar to SP:P98059 PID:556813; identified by sequence similarity; putative; Belongs to the heme-copper respiratory oxidase family.
 
  
 0.748
VC_1435
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
    0.747
VC_1438
Hypothetical protein; Identified by Glimmer2; putative.
       0.746
VC_1441
Cytochrome c oxidase, subunit CcoO; Similar to PID:1377866; identified by sequence similarity; putative.
 
  
 0.741
VC_1439
Cytochrome c oxidase, subunit CcoP; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.
 
  
 0.740
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.719
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.717
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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