Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_1447RTX toxin transporter; Similar to GP:4455068; identified by sequence similarity; putative. (467 aa)    
Predicted Functional Partners:
VC_1448
RTX toxin transporter; Similar to GP:4455067; identified by sequence similarity; putative.
 
 
 0.996
VC_1446
Toxin secretion transporter, putative; Similar to SP:P16532 GB:M24197 PID:150495 PID:150514; identified by sequence similarity; putative.
 
 
 0.991
VC_A1084
Toxin secretion ATP-binding protein; Similar to GB:L12145 GB:X68815 GB:X80055 SP:Q04473 PID:38959; identified by sequence similarity; putative.
 
 
 0.963
VC_1621
Agglutination protein; Similar to GB:M64540 PID:150976; identified by sequence similarity; putative.
 
 
 0.895
VC_1409
Multidrug resistance protein, putative; Similar to GP:3378279; identified by sequence similarity; putative.
 
 
 0.707
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
 
  
 0.693
VC_1565
Outer membrane protein TolC, putative; Similar to SP:P02930 GB:X54049 PID:43101 PID:43107 PID:882565; identified by sequence similarity; putative.
  
 
 0.656
tolC
Outer membrane protein TolC; Outer membrane channel, which is required for the function of several efflux systems (By similarity). Required to export RtxA cytotoxin; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
  
 
 0.656
rtxC
RTX toxin activating protein; Involved in fatty acylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity).
 
   
 0.647
VC_1606
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
 
 0.613
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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