STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rtxARTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...] (4558 aa)    
Predicted Functional Partners:
rtxC
RTX toxin activating protein; Involved in fatty acylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity).
 
  
 0.985
VC_0414
Hypothetical protein; Identified by Glimmer2; putative.
  
 0.973
VC_A0064
TonB system receptor, putative; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative.
 
 
 
 0.936
VC_1558
6-phospho-beta-glucosidase; Similar to PID:887851 GB:U00096 SP:Q46829 PID:2367174; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 1 family.
  
 0.932
VC_2125
Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.
  
 
 0.920
VC_0248
Acyl carrier protein, putative; Similar to GB:X59554 PID:48390; identified by sequence similarity; putative.
  
 0.912
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 0.912
tolB
tolB protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
  
 
 0.891
VC_0554
Protease, insulinase family/protease, insulinase family; Similar to GP:2661690; identified by sequence similarity; putative.
 
 
 
 0.885
VC_A0625
TonB receptor-related protein; Similar to PID:1638846; identified by sequence similarity; putative.
 
 
 
 0.884
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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