node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VC_1460 | ace | VC_1460 | VC_1459 | Hypothetical protein; Identified by Glimmer2; putative. | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | 0.785 |
VC_1460 | cep | VC_1460 | VC_1461 | Hypothetical protein; Identified by Glimmer2; putative. | Colonization factor; Similar to; identified by sequence similarity; putative. | 0.908 |
VC_1460 | ctxA | VC_1460 | VC_1457 | Hypothetical protein; Identified by Glimmer2; putative. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.652 |
VC_1460 | ctxB | VC_1460 | VC_1456 | Hypothetical protein; Identified by Glimmer2; putative. | Cholera enterotoxin, B subunit; The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | 0.650 |
VC_1460 | zot | VC_1460 | VC_1458 | Hypothetical protein; Identified by Glimmer2; putative. | Zona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). | 0.889 |
ace | VC_1460 | VC_1459 | VC_1460 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Hypothetical protein; Identified by Glimmer2; putative. | 0.785 |
ace | cep | VC_1459 | VC_1461 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Colonization factor; Similar to; identified by sequence similarity; putative. | 0.794 |
ace | ctxA | VC_1459 | VC_1457 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.711 |
ace | ctxB | VC_1459 | VC_1456 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Cholera enterotoxin, B subunit; The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | 0.671 |
ace | hlyA | VC_1459 | VC_A0219 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Haemolysin; Bacterial hemolysin that causes cytolysis by forming heptameric pores in target host membranes. | 0.443 |
ace | zot | VC_1459 | VC_1458 | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | Zona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). | 0.878 |
cep | VC_1460 | VC_1461 | VC_1460 | Colonization factor; Similar to; identified by sequence similarity; putative. | Hypothetical protein; Identified by Glimmer2; putative. | 0.908 |
cep | ace | VC_1461 | VC_1459 | Colonization factor; Similar to; identified by sequence similarity; putative. | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | 0.794 |
cep | ctxA | VC_1461 | VC_1457 | Colonization factor; Similar to; identified by sequence similarity; putative. | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | 0.678 |
cep | ctxB | VC_1461 | VC_1456 | Colonization factor; Similar to; identified by sequence similarity; putative. | Cholera enterotoxin, B subunit; The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | 0.668 |
cep | zot | VC_1461 | VC_1458 | Colonization factor; Similar to; identified by sequence similarity; putative. | Zona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). | 0.876 |
ctxA | VC_1460 | VC_1457 | VC_1460 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Hypothetical protein; Identified by Glimmer2; putative. | 0.652 |
ctxA | ace | VC_1457 | VC_1459 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops. | 0.711 |
ctxA | cep | VC_1457 | VC_1461 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Colonization factor; Similar to; identified by sequence similarity; putative. | 0.678 |
ctxA | ctxB | VC_1457 | VC_1456 | Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring. | Cholera enterotoxin, B subunit; The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | 0.999 |