STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
zotZona occludens toxin; Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens). (399 aa)    
Predicted Functional Partners:
VC_1460
Hypothetical protein; Identified by Glimmer2; putative.
     
 0.889
ace
Accessory cholera enterotoxin; Increases short-circuit current in rabbit ileal tissue mounted in Ussing chambers, by increasing the potential difference. Cultures of V.cholerae containing the cloned ace gene cause fluid secretion in ligated rabbit ileal loops.
     
 0.878
cep
Colonization factor; Similar to; identified by sequence similarity; putative.
     
 0.876
ctxA
Cholera enterotoxin, A subunit; The A1 chain catalyzes the ADP-ribosylation of Gs alpha, a GTP-binding regulatory protein, to activate the adenylate cyclase. This leads to an overproduction of cAMP and eventually to a hypersecretion of chloride and bicarbonate followed by water, resulting in the characteristic cholera stool. The A2 chain tethers A1 to the pentameric ring.
     
 0.808
ctxB
Cholera enterotoxin, B subunit; The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
     
 0.759
toxR
Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
      
 0.683
tcpA
Toxin co-regulated pilin; Constituent of pili, which may be involved in adhesion of V.cholerae to the host intestinal epithelium.
      
 0.607
VC_1463
RstA2 protein; Similar to GP:2564352; identified by sequence similarity; putative.
  
  
 0.605
hlyA
Haemolysin; Bacterial hemolysin that causes cytolysis by forming heptameric pores in target host membranes.
      
 0.509
VC_1462
RstB2 protein; Similar to GP:2564358; identified by sequence similarity; putative.
     
 0.507
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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