Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nhaANa+/H+ antiporter protein; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Contributes to the survival of V.cholerae during the stationary and exponential growth phases in a saline environment. (382 aa)    
Predicted Functional Partners:
nhaB
Na+/H+ antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
  
   
 0.860
kefB
Glutathione-regulated potassium-efflux system protein KefB; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.
 
   
 0.764
VC_1628
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.685
VC_1629
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.685
VC_1630
ABC transporter, ATP-binding protein; Similar to GB:AE000782; identified by sequence similarity; putative.
       0.685
VC_1631
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.624
VC_1632
Conserved hypothetical protein; Identified by Glimmer2; putative.
       0.587
nhaP2
Conserved hypothetical protein; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
     
 0.577
nhaR
Transcriptional activator protein NhaR; Plays a role in the positive regulation of NhaA. Belongs to the LysR transcriptional regulatory family.
  
  
 0.576
VC_0136
Conserved hypothetical protein; Involved in positive regulation of motility and negative regulation of biofilm formation.
      
 0.553
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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