Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_1706Transcriptional activator MetR; Similar to GB:M17356 SP:P05984 PID:154177; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family. (305 aa)    
Predicted Functional Partners:
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
   
 0.820
VC_1049
Transcriptional regulator, LysR family; Similar to GP:1139588; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.645
VC_1705
Hypothetical protein; Identified by Glimmer2; putative.
       0.623
VC_A0833
Transcriptional regulator, LysR family; Similar to GB:AE000657; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.574
VC_A0756
Transcriptional regulator, LysR family; Similar to GB:X73124 SP:P39647 PID:580884 GB:AL009126; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.556
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.542
VC_A0889
Transcriptional regulator, LysR family; Similar to PID:924993 SP:P52689; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.522
VC_A1058
Transcriptional regulator, LysR family; Similar to PID:1493807; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.
  
     0.521
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.516
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
    
 
 0.513
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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