Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Experiments
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[Homology]
Score
VC_1809Transcriptional regulator, putative; Similar to SP:P12552 PID:15163 PID:15171; identified by sequence similarity; putative. (76 aa)    
Predicted Functional Partners:
VC_1758
Integrase, phage family; Similar to GB:U02372 PID:498253 PID:1100883; identified by sequence similarity; putative; Belongs to the 'phage' integrase family.
 
  
 0.881
VC_0516
Phage integrase; Similar to SP:P32053 GB:U03737 PID:216669 PID:433349 PID:1033117; identified by sequence similarity; putative; Belongs to the 'phage' integrase family.
 
  
 0.758
VC_A0281
Integrase, putative; Similar to GP:3294478; identified by sequence similarity; putative; Belongs to the 'phage' integrase family.
 
  
 0.757
VC_0847
Integrase, phage family; Similar to GB:U02372 PID:498253 PID:1100883; identified by sequence similarity; putative; Belongs to the 'phage' integrase family.
 
  
 0.756
vgrG3
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus. Toxicity is counteracted by a cognate immunity protein TsiV3.
  
    0.425
vgrG1
vgrG protein; Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of ano [...]
   
    0.419
vgrG2
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co- regulated protein Hcp. Allows the delivery of the VasX antibacterial toxin to target cells where it exerts its toxicity.
   
    0.419
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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