Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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pyrFOrotidine 5`-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.997
pyrB
Aspartate carbamoyltransferase, catalytic subunit; Similar to PID:1708787; identified by sequence similarity; putative.
  
  
 0.968
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
  
 0.966
upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.962
carB
Carbamoyl-phosphate synthase, large subunit; Similar to GB:D10483 SP:P00968 GB:J01597 GB:V01500 PID:145464; identified by sequence similarity; putative.
  
  
 0.956
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.932
VC_0312
NAD(P)H-flavin reductase; Similar to GB:D14674 GB:D17746 SP:P43127 PID:498172 PID:511944; identified by sequence similarity; putative.
  
  
 0.929
carA
Carbamoyl-phosphate synthase, small subunit; Similar to GB:D10483 SP:P00907 GB:J01597 PID:285764 PID:551790; identified by sequence similarity; putative; Belongs to the CarA family.
  
  
 0.928
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.922
udk
Uridine kinase; Similar to SP:P31218 GB:X71492 PID:296947 GB:U00096 PID:1736770; identified by sequence similarity; putative.
  
 
 0.911
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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