Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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VC_20862-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa)    
Predicted Functional Partners:
VC_2087
2-oxoglutarate dehydrogenase, E1 component; Similar to GB:J01619 SP:P07015 PID:146201 PID:43019 GB:U00096; identified by sequence similarity; putative.
 0.999
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.998
lpd
Pyruvate dehydrogenase, E3 component, lipoamide dehydrogenase; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
 0.997
sucD
succinyl-CoA synthase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.996
VC_2638
Pyridine nucleotide-disulfide oxidoreductase, class I; Similar to GB:AL009126; identified by sequence similarity; putative.
 
 0.992
sthA
Pyridine nucleotide-disulfide oxidoreductase, class I; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 0.951
VC_2414
Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 
 0.951
VC_2092
Citrate synthase; Similar to GB:J01619 SP:P00891 GB:M28987 GB:M28988 GB:V01501; identified by sequence similarity; putative; Belongs to the citrate synthase family.
 
 0.942
VC_0186
Glutathione reductase; Similar to SP:P06715 GB:M13141 PID:146248 PID:466637 GB:U00096; identified by sequence similarity; putative.
 0.926
VC_2088
Succinate dehydrogenase, iron-sulfur protein; Similar to PID:2239250; identified by sequence similarity; putative; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.910
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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