STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
viuBVibriobactin utilization protein ViuB; Involved in intracellular removal of iron from iron- vibriobactin complex. Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm (By similarity); Belongs to the SIP oxidoreductase family. (271 aa)    
Predicted Functional Partners:
vibB
Vibriobactin-specific isochorismatase; Involved in the biosynthesis of the catechol siderophore vibriobactin. Vibriobactin is a chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm; Belongs to the isochorismatase family.
 
  
 0.915
VC_1446
Toxin secretion transporter, putative; Similar to SP:P16532 GB:M24197 PID:150495 PID:150514; identified by sequence similarity; putative.
   
  0.906
VC_1448
RTX toxin transporter; Similar to GP:4455067; identified by sequence similarity; putative.
   
  0.906
VC_A1084
Toxin secretion ATP-binding protein; Similar to GB:L12145 GB:X68815 GB:X80055 SP:Q04473 PID:38959; identified by sequence similarity; putative.
   
  0.906
VC_0775
Vibriobactin synthesis protein, putative; Similar to GB:M60177 SP:P11454 GB:M17354 PID:145843 PID:551801; identified by sequence similarity; putative.
 
  
 0.836
vibE
Vibriobactin-specific 2,3-dihydroxybenzoate-AMP ligase; Activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate, preparing that molecule for the final stages of vibriobactin synthesis.
 
  
 0.814
viuA
Ferric vibriobactin receptor; Receptor for ferric vibriobactin; Belongs to the TonB-dependent receptor family.
 
  
 0.728
irgA
Iron-regulated outer membrane virulence protein, TonB receptor family; Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment; Belongs to the TonB-dependent receptor family.
 
  
 0.638
VC_A0227
iron(III) ABC transporter, periplasmic iron-compound-binding protein; Similar to GB:AL009126; identified by sequence similarity; putative.
 
  
 0.505
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
  
 0.501
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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