STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_2346Smp protein, putative; Similar to SP:P18838 GB:M30784 GB:X03046 PID:432633 PID:436177; identified by sequence similarity; putative. (228 aa)    
Predicted Functional Partners:
cqsS
Sensor histidine kinase/response regulator LuxN; Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO.
  
  
  0.877
VC_2369
Sensor histidine kinase FexB; Similar to SP:P22763 GB:X53315 PID:40951 PID:606149 GB:U00096; identified by sequence similarity; putative.
  
  
  0.829
VC_2453
Sensor histidine kinase/response regulator; Similar to GB:D10888 SP:P26607 PID:216535 PID:882680 GB:U00096; identified by sequence similarity; putative.
  
  
  0.790
luxQ
Sensor histidine kinase LuxQ; At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity (By similarity).
  
  
  0.776
bamC
Lipoprotein-34 NlpB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
   
 0.775
VC_2739
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.773
ompU
Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane.
  
   
 0.770
VC_1841
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.770
VC_A1114
ParB family protein; Similar to SP:P08867 GB:M12987 GB:X04619 PID:148592 PID:42432; identified by sequence similarity; putative; Belongs to the ParB family.
  
     0.769
VC_1153
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
     0.767
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.