Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pilCType IV pilin biogenesis protein PilC; Involved in the translocation of the type IV pilin; Belongs to the GSP F family. (408 aa)    
Predicted Functional Partners:
VC_2424
Type IV pilus assembly protein PilB; Similar to GP:3220230; identified by sequence similarity; putative.
 
 
 0.983
epsE
General secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
 
 
 0.966
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
 
 
 0.962
VC_2426
Leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
 
  
 0.961
tcpJ
Leader peptidase TcpJ; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the TcpA pilin precursor during membrane translocation.
 
  
 0.956
VC_0405
MSHA biogenesis protein MshE; Similar to PID:791156 PID:791159; identified by sequence similarity; putative.
 
 
 0.954
VC_2423
Fimbrial protein; Similar to GB:M24281 SP:P08015 SP:P17837 GB:M14850 PID:151463; identified by sequence similarity; putative; Belongs to the N-Me-Phe pilin family.
 
   
 0.935
VC_2634
Fimbrial assembly protein PilM, putative; Similar to GB:L28837 PID:895925; identified by sequence similarity; putative.
 
 
 
 0.920
VC_2630
Fimbrial assembly protein; Similar to GB:L13865 SP:P34750 PID:459551; identified by sequence similarity; putative.
 
 
 
 0.909
VC_2632
Fimbrial assembly protein PilO, putative; Similar to GB:U12892 PID:530858; identified by sequence similarity; putative.
 
 
 
 0.848
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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