STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_2426Leader peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (291 aa)    
Predicted Functional Partners:
pilC
Type IV pilin biogenesis protein PilC; Involved in the translocation of the type IV pilin; Belongs to the GSP F family.
 
  
 0.945
VC_2424
Type IV pilus assembly protein PilB; Similar to GP:3220230; identified by sequence similarity; putative.
 
 
 0.936
coaE
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.879
VC_2423
Fimbrial protein; Similar to GB:M24281 SP:P08015 SP:P17837 GB:M14850 PID:151463; identified by sequence similarity; putative; Belongs to the N-Me-Phe pilin family.
 
   
 0.878
epsE
General secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane.
 
 
 0.875
VC_0405
MSHA biogenesis protein MshE; Similar to PID:791156 PID:791159; identified by sequence similarity; putative.
 
 
 0.871
tcpT
Toxin co-regulated pilus biosynthesis protein T; Involved in the translocation of the TcpA pilin.
 
 
 0.871
VC_0406
MSHA biogenesis protein MshG; Similar to PID:1016255 PID:1016256; identified by sequence similarity; putative.
 
  
 0.864
epsF
General secretion pathway protein F; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane.
 
  
 0.861
VC_0462
Twitching motility protein PilT; Similar to SP:P24559 GB:X67095 PID:151490; identified by sequence similarity; putative.
 
   
 0.809
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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