STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_2466sigma-E factor negative regulatory protein RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplas [...] (212 aa)    
Predicted Functional Partners:
VC_2465
sigma-E factor regulatory protein RseB; Similar to SP:P46186 PID:1050876 PID:987646 PID:1045630 GB:U00096; identified by sequence similarity; putative.
 
 
 0.997
VC_2467
RNA polymerase sigma-E factor; Similar to PID:777747 PID:780317; identified by sequence similarity; putative; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.989
VC_2302
RNA polymerase sigma-70 factor, ECF subfamily; Similar to PID:1654108; identified by sequence similarity; putative; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.944
VC_1044
Hypothetical protein; Identified by Glimmer2; putative.
 
 
 0.942
VC_1045
RNA polymerase sigma-70 factor, ECF subfamily; Similar to GB:AL009126; identified by sequence similarity; putative; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.921
VC_2464
sigma-E factor regulatory protein RseC; Similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096; identified by sequence similarity; putative.
 
  
 0.917
VC_0565
Protease DegS; Similar to SP:P31137 GB:U15661 GB:U00096 PID:1789630; identified by sequence similarity; putative.
  
 
 0.905
VC_0566
Protease DO; Similar to GB:M36536 SP:P09376 GB:M29955 GB:X12457 PID:146414; identified by sequence similarity; putative; Belongs to the peptidase S1C family.
  
 
 0.903
VC_0577
Stringent starvation protein B; Similar to GB:M69028 SP:P25663 GB:X05088 PID:147872 PID:42999; identified by sequence similarity; putative.
    
 
 0.858
VC_0648
Conserved hypothetical protein; May be involved in cell division.
  
   
 0.753
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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