Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VC_2748Nitrogen regulation protein; Similar to SP:P19906 PID:155172; identified by sequence similarity; putative. (354 aa)    
Predicted Functional Partners:
ntrC
Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.
 0.997
VC_2239
Nitrogen regulatory protein P-II; Similar to SP:P11671 PID:43806; identified by sequence similarity; putative; Belongs to the P(II) protein family.
  
 0.989
VC_0606
Nitrogen regulatory protein P-II; Similar to GB:U00096 PID:1788904 PID:1799977; identified by sequence similarity; putative; Belongs to the P(II) protein family.
  
 
 0.898
glnAv
Glutamate--ammonia ligase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.
 
  
 0.890
VC_2750
GGDEF family protein; Similar to PID:1653584; identified by sequence similarity; putative.
     
 0.817
VC_A0704
Phosphoglycerate transport system transcriptional regulatory protein PgtA; Similar to GB:M13923 SP:P06184 PID:154255; identified by sequence similarity; putative.
 
 
 0.807
glnD
protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
  
 
 
 0.799
VC_A0142
C4-dicarboxylate transport transcriptional regulatory protein; Similar to SP:P10046 GB:X06253 GB:Z11529 PID:46180 PID:46183; identified by sequence similarity; putative.
 
 
 0.787
VC_2135
Sigma-54 dependent response regulator; Similar to PID:2352978; identified by sequence similarity; putative.
 
 
 0.786
luxO
LuxO repressor protein; Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress, perhaps indirectly, some genes.
 
 
 0.783
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.