node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
VC_2195 | vasX | VC_2195 | VC_A0020 | Flagellar basal-body rod protein FlgG; Similar to GB:U00096 SP:P75939 PID:1787318; identified by sequence similarity; putative; Belongs to the flagella basal body rod proteins family. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.648 |
VC_2662 | vasX | VC_2662 | VC_A0020 | Conserved hypothetical protein; Identified by Glimmer2; putative. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.808 |
VC_A0017 | tsiV2 | VC_A0017 | VC_A0021 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | 0.640 |
VC_A0017 | vasW | VC_A0017 | VC_A0019 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | Hypothetical protein; Plays an accessory role in VasX-mediated bacterial killing. | 0.564 |
VC_A0017 | vasX | VC_A0017 | VC_A0020 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.653 |
VC_A0017 | vgrG1 | VC_A0017 | VC_1416 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | vgrG protein; Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of ano [...] | 0.914 |
VC_A0017 | vgrG2 | VC_A0017 | VC_A0018 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co- regulated protein Hcp. Allows the delivery of the VasX antibacterial toxin to target cells where it exerts its toxicity. | 0.955 |
VC_A0017 | vgrG3 | VC_A0017 | VC_A0123 | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus. Toxicity is counteracted by a cognate immunity protein TsiV3. | 0.918 |
guaA | guaB | VC_0768 | VC_0767 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | vasX | VC_0768 | VC_A0020 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.807 |
guaB | guaA | VC_0767 | VC_0768 | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | vasX | VC_0767 | VC_A0020 | Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.763 |
tsiV2 | VC_A0017 | VC_A0021 | VC_A0017 | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | 0.640 |
tsiV2 | vasW | VC_A0021 | VC_A0019 | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | Hypothetical protein; Plays an accessory role in VasX-mediated bacterial killing. | 0.851 |
tsiV2 | vasX | VC_A0021 | VC_A0020 | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.931 |
tsiV2 | vgrG2 | VC_A0021 | VC_A0018 | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co- regulated protein Hcp. Allows the delivery of the VasX antibacterial toxin to target cells where it exerts its toxicity. | 0.827 |
tsiV2 | vgrG3 | VC_A0021 | VC_A0123 | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus. Toxicity is counteracted by a cognate immunity protein TsiV3. | 0.405 |
vasW | VC_A0017 | VC_A0019 | VC_A0017 | Hypothetical protein; Plays an accessory role in VasX-mediated bacterial killing. | Hcp protein; Similar to GP:1488371; identified by sequence similarity; putative. | 0.564 |
vasW | tsiV2 | VC_A0019 | VC_A0021 | Hypothetical protein; Plays an accessory role in VasX-mediated bacterial killing. | Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin VasX. | 0.851 |
vasW | vasX | VC_A0019 | VC_A0020 | Hypothetical protein; Plays an accessory role in VasX-mediated bacterial killing. | Hypothetical protein; Toxin secreted by the type VI (T6SS) secretion system that acts on prokaryotic target cells. Acts in conjunction with VasW, an accessory protein to VasX, to compromise the inner membrane of prokaryotic target cells. | 0.926 |