Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_A0064TonB system receptor, putative; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative. (713 aa)    
Predicted Functional Partners:
VC_A0065
Hypothetical protein; Identified by Glimmer2; putative.
 
     0.937
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
 
 
 
 0.896
tonB
tonB1 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
 
 
 0.883
VC_1544
tonB2 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.877
VC_A0066
Hypothetical protein; Identified by Glimmer2; putative.
 
     0.861
VC_A0067
Hypothetical protein; Identified by Glimmer2; putative.
 
     0.856
VC_A0063
Protease II; Similar to GB:D10976 SP:P24555 PID:216624 GB:U00096 PID:1736485; identified by sequence similarity; putative.
 
     0.837
VC_A0849
Hypothetical protein; Identified by Glimmer2; putative.
  
 
 
 0.713
exbD1
TonB system transport protein ExbD1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
  
 0.703
exbD2
TonB system transport protein ExbD2; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
  
 0.665
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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