Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0132Ribose operon repressor; Similar to GB:L10328 SP:P25551 GB:D10466 GB:M13169 PID:147517; identified by sequence similarity; putative. (334 aa)    
Predicted Functional Partners:
rbsK
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.909
rbsD
Ribose ABC transporter protein; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
 
  
 0.862
VC_A0129
Ribose ABC transporter, permease protein; Similar to GB:L10328 SP:P04984 GB:M13169 PID:147514 PID:290600; identified by sequence similarity; putative; Belongs to the binding-protein-dependent transport system permease family.
  
  
 0.832
VC_A0130
Ribose ABC transporter, periplasmic D-ribose-binding protein; Similar to GB:L42023 SP:P44737 PID:1003892 PID:1222436 PID:1204755; identified by sequence similarity; putative.
 
  
0.791
VC_2373
Glutamate synthase, large subunit; Similar to GB:X80485 PID:515938 SP:P55037 PID:1652093; identified by sequence similarity; putative.
    
 
 0.764
VC_2376
Glutamate synthase, large subunit; Similar to PID:606151 GB:U00096 PID:1789605; identified by sequence similarity; putative.
    
 
 0.764
rbsA
Ribose ABC transporter, ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
  
  
 0.654
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
   0.622
vibB
Vibriobactin-specific isochorismatase; Involved in the biosynthesis of the catechol siderophore vibriobactin. Vibriobactin is a chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm; Belongs to the isochorismatase family.
    
   0.596
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 
 0.589
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.