Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_A0211Sensory box sensor histidine kinase; Similar to PID:561864; identified by sequence similarity; putative. (648 aa)    
Predicted Functional Partners:
VC_A0212
Hypothetical protein; Identified by Glimmer2; putative.
 
     0.755
VC_A0210
Response regulator, putative; Phosphodiesterase (PDE) that catalyzes the hydrolysis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP), leading to linear 5'-pApG. Counteracts the function of the 3'3'-cGAMP synthase DncV, and is involved in the modulation of intracellular 3'3'-cGAMP levels. Enhances bacterial chemotaxis and inhibits intestinal colonization in vivo. Thus exerts a crucial role in regulating bacterial infectivity through catalyzing 3'3'-cGAMP degradation. Is specific for 3'3'-cGAMP since it cannot degrade other cGAMP linkage isomers (3'2'-, 2'3'-, and 2'2'-cGAMPs). Is also able to hydrol [...]
 
 
 
 0.741
VC_1349
Sensory box sensor histidine kinase/response regulator; Similar to PID:1653075; identified by sequence similarity; putative.
 
 
0.694
VC_1087
Response regulator; Similar to GB:M63670 SP:P26408 GB:X61007 PID:151907 PID:46054; identified by sequence similarity; putative.
 
 
 
 0.675
VC_1598
ABC transporter, periplasmic substrate-binding protein-related protein; Similar to GB:L42023 PID:1006358 PID:1221197 PID:1205330 SP:P45024; identified by sequence similarity; putative.
  
     0.647
VC_2369
Sensor histidine kinase FexB; Similar to SP:P22763 GB:X53315 PID:40951 PID:606149 GB:U00096; identified by sequence similarity; putative.
 
 
0.645
VC_A1086
Response regulator; Similar to PID:1653310; identified by sequence similarity; putative.
 
 
 
 0.640
VC_1348
Response regulator; Probable phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Increases motility and decreases biofilm formation in vivo.
 
 
 0.607
VC_0303
Sensor histidine kinase; Similar to GP:2808665; identified by sequence similarity; putative.
  
 
 0.603
VC_A0182
Sigma-54 dependent transcriptional regulator; Similar to SP:P37013 GB:D28595 GB:U03846 PID:434587 PID:434588; identified by sequence similarity; putative.
   
 
 0.582
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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