STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0218Thermolabile hemolysin; Similar to GB:M36437 SP:Q99289 PID:155178; identified by sequence similarity; putative. (418 aa)    
Predicted Functional Partners:
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
  
  
 0.801
VC_2213
Outer membrane protein OmpA; Similar to GP:2641145; identified by sequence similarity; putative; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
    
 
 0.776
VC_A0065
Hypothetical protein; Identified by Glimmer2; putative.
  
   
 0.775
lifO
Lipase activator protein, putative; May be involved in the folding of the extracellular lipase during its passage through the periplasm; Belongs to the lipase chaperone family.
  
   
 0.739
VC_A0085
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.735
vcc
Collagenase; Possesses gelatinolytic activity; Belongs to the peptidase M9A family.
  
   
 0.701
hap
Hemagglutinin/protease; May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins.
  
   
 0.680
VC_1983
Peptidase, putative; Similar to SP:P47788 PID:1871406 PID:565284; identified by sequence similarity; putative.
  
     0.678
VC_1644
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.640
rtxC
RTX toxin activating protein; Involved in fatty acylation of the protoxin (RtxA) at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP (By similarity).
  
   
 0.637
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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