Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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prtVProtease; Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen. (918 aa)    
Predicted Functional Partners:
hap
Hemagglutinin/protease; May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins.
  
  
 0.863
VC_A0224
Hypothetical protein; Identified by Glimmer2; putative.
       0.750
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
 
   
 0.716
VC_A0065
Hypothetical protein; Identified by Glimmer2; putative.
  
   
 0.668
VC_0157
Alkaline serine protease; Similar to GB:M25499 SP:P16588 PID:155251; identified by sequence similarity; putative; Belongs to the peptidase S8 family.
 
  
 0.654
VC_1983
Peptidase, putative; Similar to SP:P47788 PID:1871406 PID:565284; identified by sequence similarity; putative.
  
    0.648
VC_0278
Transcriptional activator CadC, putative; Similar to SP:P23890 GB:M67452 PID:145452 PID:536978 GB:U00096; identified by sequence similarity; putative.
  
   
 0.638
VC_1606
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
 
 
 0.607
VC_A0140
Spindolin-related protein; Similar to PID:1145625; identified by sequence similarity; putative.
 
  
 0.602
VC_1644
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.601
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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