Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
VC_A0254Hypothetical protein; Identified by Glimmer2; putative. (722 aa)    
Predicted Functional Partners:
VC_A0255
Hypothetical protein; Identified by Glimmer2; putative.
       0.747
VC_2640
Hypothetical protein; Identified by Glimmer2; putative.
    
 
 0.689
VC_A0257
Sensor histidine kinase; Similar to PID:1001492 PID:1001594; identified by sequence similarity; putative.
 
  
 0.650
rpsO
Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
    
   0.642
vgrG3
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and targets the cell wall peptidoglycan layer of prey cells for degradation via its C-terminus. Toxicity is counteracted by a cognate immunity protein TsiV3.
  
   0.639
VC_0769
Chitinase, putative; Similar to SP:P08252 PID:19861 PID:19863 PID:512387; identified by sequence similarity; putative.
  
     0.636
vgrG1
vgrG protein; Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp. Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity. Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin. Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of ano [...]
  
   0.636
vgrG2
vgrG protein; Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co- regulated protein Hcp. Allows the delivery of the VasX antibacterial toxin to target cells where it exerts its toxicity.
  
   0.636
VC_2622
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.595
VC_0622
Sensory box sensor histidine kinase/response regulator; Similar to PID:939724; identified by sequence similarity; putative.
  
  
 0.590
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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