Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
higA-2Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB-2 toxin. Binds to its own promoter and regulates transcription of the higB-2/higA-2 operon. (104 aa)    
Predicted Functional Partners:
higB-2
Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Inhibits translation by cleavage of mRNA.
 
 
 
 0.998
higA-1
Antidote protein, putative; Antitoxin component of a type II toxin-antitoxin (TA) system that counteracts the effect of the HigB-1 toxin. Binds to its own promoter and regulates transcription of the higB-1/higA-1 operon.
 
   
 0.768
higB-1
Killer protein, putative; Toxic component of a type II toxin-antitoxin (TA) system. Inhibits translation by cleavage of mRNA.
 
   
 0.745
VC_0139
DPS family protein; Similar to GB:L42023 SP:P45173 PID:1007363 PID:1221482 PID:1205585; identified by sequence similarity; putative; Belongs to the Dps family.
   
    0.623
VC_A0489
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
   
 0.578
VC_A0467
Hypothetical protein; Identified by Glimmer2; putative.
       0.522
VC_A0447
Haemagglutinin associated protein; Similar to GB:X64387 PID:396849 PID:48357; identified by sequence similarity; putative; Belongs to the N(4)/N(6)-methyltransferase family.
   
   0.488
VC_A0470
Acetyltransferase, putative; Similar to GB:U00096 PID:1788774; identified by sequence similarity; putative.
       0.486
VC_1872
Conserved hypothetical protein; Identified by Glimmer2; putative.
   
    0.485
era
GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
   
   0.466
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.