STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A05455`-nucleotidase, putative; Similar to GB:AE000520; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family. (580 aa)    
Predicted Functional Partners:
VC_2562
2`,3`-cyclic-nucleotide 2`-phosphodiesterase; Similar to SP:P08331 GB:M13464 PID:145584 GB:U00096 PID:1790658; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
 
 
 0.989
VC_A0608
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
 
 0.968
nutA
UDP-sugar hydrolase; Degradation of extracellular 5'-nucleotides for nutritional needs.
  
  
0.941
VC_2416
2`,3`-cyclic-nucleotide 2`-phosphodiesterase, putative; Similar to GB:AE000511 PID:2313187; identified by sequence similarity; putative; Belongs to the 5'-nucleotidase family.
 
 
 
0.929
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.926
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.921
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
   
 
 0.918
VC_1129
Inosine-guanosine kinase; Similar to GB:D00798 SP:P22937 PID:216562 PID:520811 PID:216519; identified by sequence similarity; putative.
 
  
 0.916
VC_A0801
Inosine-guanosine kinase; Similar to GB:D00798 SP:P22937 PID:216562 PID:520811 PID:216519; identified by sequence similarity; putative.
 
  
 0.916
guaC
GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
   
 0.913
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: very high (100%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.