STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0556Hypothetical protein; Identified by Glimmer2; putative. (184 aa)    
Predicted Functional Partners:
nanH
Neuraminidase; Cleaves the terminal sialic acid (N-acetyl neuraminic acid) from carbohydrate chains in glycoproteins providing free sialic acid which can be used as carbon and energy sources. Sialidases have been suggested to be pathogenic factors in microbial infections. Facilitates cholera toxin binding to host intestinal epithelial cells by converting cell surface polysialogangliosides to GM1 monogangliosides; Belongs to the glycosyl hydrolase 33 family.
  
     0.598
VC_A0554
Oxalate/formate antiporter, putative; Similar to GB:AE000782; identified by sequence similarity; putative.
 
     0.548
VC_2305
Outer membrane protein OmpK; Similar to PID:1166401 SP:P51002; identified by sequence similarity; putative.
  
     0.498
VC_A0555
Hypothetical protein; Identified by Glimmer2; putative.
       0.468
VC_1224
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.444
nanM
Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family.
  
     0.425
VC_1505
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.422
VC_0317
Hypothetical protein; Identified by Glimmer2; putative.
  
     0.420
VC_A0557
GGDEF family protein; Similar to GB:U00096 SP:P75908 PID:1787262; identified by sequence similarity; putative.
       0.415
VC_1853
Conserved hypothetical protein; Identified by Glimmer2; putative; Belongs to the UPF0319 family.
  
     0.409
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.