STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0574Conserved hypothetical protein; Identified by Glimmer2; putative. (893 aa)    
Predicted Functional Partners:
VC_A0530
Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative.
  
 0.964
VC_1340
prpE protein; Similar to GB:U00096 SP:P77495 PID:1657531 PID:1786529; identified by sequence similarity; putative.
 
  
 0.895
acsA
acetyl-CoA synthase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
  
 0.886
VC_A0829
acetyl-CoA synthase; Similar to GB:AE000782; identified by sequence similarity; putative.
 
  
 0.884
pta
Phosphate acetyltransferase; Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.
    
 0.875
VC_2033
Alcohol dehydrogenase/acetaldehyde dehydrogenase; Similar to GB:M33504 SP:P17547 GB:X59263 GB:X67326 PID:145206; identified by sequence similarity; putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
    
 0.869
argD
Acetylornithine aminotransferase; Similar to GB:M32796 SP:P18335 PID:145337 PID:606293 GB:U00096; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
    
 0.842
fadJ
Fatty oxidation complex, alpha subunit; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
  
 
 0.839
fadB
Fatty oxidation complex, alpha subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
  
 
 0.839
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
   0.831
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.