Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
VC_A0720Guanylate cyclase-related protein; Similar to PID:861203; identified by sequence similarity; putative. (191 aa)    
Predicted Functional Partners:
VC_1711
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
  
 0.926
VC_A0719
Sensor histide kinase; Similar to GB:L13078 SP:Q06067 PID:290419 GB:U00096 PID:1736874; identified by sequence similarity; putative.
 
   
 0.838
VC_A0080
GGDEF family protein; Similar to GP:6759486; identified by sequence similarity; putative.
  
  
 0.627
VC_A0172
Conserved hypothetical protein; Identified by Glimmer2; putative.
   
 
 0.564
VC_0728
Conserved hypothetical protein; Identified by Glimmer2; putative.
   
    0.551
VC_0964
PTS system, glucose-specific IIA component; Similar to GB:J02796 SP:P08837 GB:M93578 GB:M93579 GB:M93580; identified by sequence similarity; putative.
      
 0.547
VC_1302
MutT/nudix family protein; Similar to SP:P43337 GB:U00096 PID:1788115; identified by sequence similarity; putative.
 
     0.545
VC_A0721
Hypothetical protein; Identified by Glimmer2; putative.
       0.534
cdpA
GGDEF family protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) a [...]
     
 0.494
VC_1300
L-serine dehydratase 1; Similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451; identified by sequence similarity; putative; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
    0.443
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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