STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0765L-allo-threonine aldolase; Similar to GB:U00096 SP:P75823 PID:1787095 PID:2225892; identified by sequence similarity; putative. (343 aa)    
Predicted Functional Partners:
VC_A0764
MutT/nudix family protein; Similar to SP:P54570 PID:1303984 GB:AL009126; identified by sequence similarity; putative.
       0.799
VC_A0766
Cytochrome c554; Similar to SP:P00105; identified by sequence similarity; putative.
       0.799
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.734
VC_2362
Threonine synthase; Similar to GB:L42023 SP:P44503 PID:1003078 PID:1221997 PID:1204345; identified by sequence similarity; putative.
  
 0.734
ychF
GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
      0.725
glyA1
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.718
glyA2
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.718
VC_1977
Aspartate aminotransferase, putative; Similar to GB:U00096 PID:1788627 PID:1799660; identified by sequence similarity; putative.
  
 
 0.704
VC_0392
Aminotransferase, class V; Similar to SP:P31030 PID:164759; identified by sequence similarity; putative.
    
 0.672
VC_A1057
Oxidoreductase, short-chain dehydrogenase/reductase family; Similar to PID:1001780 PID:1001805; identified by sequence similarity; putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
  0.648
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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