STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pxpAConserved hypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (246 aa)    
Predicted Functional Partners:
VC_A0777
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
 0.998
VC_A0778
Conserved hypothetical protein; Identified by Glimmer2; putative.
 
 0.993
aldA
Aldehyde dehydrogenase; May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.
   
 
  0.643
VC_1745
Succinate-semialdehyde dehydrogenase; Similar to GB:M88334 SP:P25526 PID:147901 GB:U00096 PID:1789015; identified by sequence similarity; putative; Belongs to the aldehyde dehydrogenase family.
   
 
  0.643
VC_1819
Aldehyde dehydrogenase; Similar to GB:M60658 SP:P23240 PID:155276; identified by sequence similarity; putative; Belongs to the aldehyde dehydrogenase family.
   
 
  0.643
astD
Succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
   
 
  0.643
VC_A1067
Aldehyde dehydrogenase; Similar to SP:P12693 PID:49082; identified by sequence similarity; putative; Belongs to the aldehyde dehydrogenase family.
   
 
  0.643
VC_2033
Alcohol dehydrogenase/acetaldehyde dehydrogenase; Similar to GB:M33504 SP:P17547 GB:X59263 GB:X67326 PID:145206; identified by sequence similarity; putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
   
 
  0.631
VC_2546
Conserved hypothetical protein; Putative gamma-glutamylcyclotransferase.
    
  0.624
VC_A1071
Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
    0.621
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.