Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hapHemagglutinin/protease; May play a role in the pathogenesis of cholera. Hap nicks and activates the A subunit of cholera enterotoxin and related enterotoxins. (609 aa)    
Predicted Functional Partners:
prtV
Protease; Metalloprotease that exhibits a cytotoxic effect leading to cell death. In host tissues, it could play a role in pathogenesis by modulating the stability of the extracellular matrix components such as fibronectin and fibrinogen. Also able to cleave plasminogen.
  
  
 0.863
rtxA
RTX toxin RtxA; [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain): the protease activity is activated upon binding inositol hexakisphosphate (InsP6) present at the host cell membrane and delivers the Cysteine protease domain-containing toxin F3 chain to the host [...]
 
  
 0.777
gbpA
Chitinase, putative; Probably interacts with GlcNAc residues. May promote attachment to both epithelial cell surfaces and chitin. This function enhances bacterial colonization in the gastrointestinal tract and may also be important in the environment by augment colonization of chitinous structures, leading to improved survival. Promotes bacterial attachment to, and colonization of, zooplankton in the aquatic ecosystem; Belongs to the GbpA family.
  
  
 0.771
vcc
Collagenase; Possesses gelatinolytic activity; Belongs to the peptidase M9A family.
  
  
 0.760
VC_A0218
Thermolabile hemolysin; Similar to GB:M36437 SP:Q99289 PID:155178; identified by sequence similarity; putative.
  
   
 0.757
VC_A0140
Spindolin-related protein; Similar to PID:1145625; identified by sequence similarity; putative.
  
  
 0.699
VC_A0027
Chitinase; Similar to SP:P32823 PID:216207; identified by sequence similarity; putative.
 
  
 0.664
rpoS
RNA polymerase sigma-38 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response (By similarity). May be required for the persistence of V.cholerae in aquatic habitats.
   
  
 0.642
VC_1952
Chitinase; Similar to GP:3851166; identified by sequence similarity; putative.
 
  
 0.609
VC_A0813
Aminopeptidase; Similar to PID:1694931; identified by sequence similarity; putative.
 
  
0.585
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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