Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ompWOuter membrane protein OmpW; Similar to SP:P17266 PID:48376 PID:2199526; identified by sequence similarity; putative. (217 aa)    
Predicted Functional Partners:
VC_1441
Cytochrome c oxidase, subunit CcoO; Similar to PID:1377866; identified by sequence similarity; putative.
 
    0.831
VC_0116
Oxygen-independent coproporphyrinogen III oxidase; Similar to GB:L19201 SP:P32131 GB:X82073 PID:1220106 PID:304972; identified by sequence similarity; putative; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
  
 0.815
VC_A0909
Oxygen-independent coproporphyrinogen III oxidase, putative; Similar to SP:P54304 PID:1303805 GB:AL009126; identified by sequence similarity; putative.
  
  
 0.739
ompU
Outer membrane protein OmpU; Forms pores that allow passive diffusion of small molecules across the outer membrane.
  
   
 0.686
VC_0036
FixG-related protein; Similar to PID:2398782; identified by sequence similarity; putative.
 
  
 0.681
VC_0728
Conserved hypothetical protein; Identified by Glimmer2; putative.
   
    0.676
VC_1442
Cytochrome c oxidase, subunit CcoN; Similar to SP:P98059 PID:556813; identified by sequence similarity; putative; Belongs to the heme-copper respiratory oxidase family.
  
  
 0.675
toxR
Cholera toxin transcriptional activator; This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT.
      
 0.666
arcA
Arginine deiminase; Similar to GB:X14694 SP:P13981 GB:S43866 PID:45286; identified by sequence similarity; putative.
   
    0.646
VC_0089
Cytochrome c551 peroxidase; Similar to GB:AE000657; identified by sequence similarity; putative.
   
  
 0.625
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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