STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
tonBtonB1 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity). (249 aa)    
Predicted Functional Partners:
exbB1
TonB system transport protein ExbB1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
 
 
 0.994
exbD1
TonB system transport protein ExbD1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
 
 0.994
exbD2
TonB system transport protein ExbD2; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
 
 0.972
tolR
tolR membrane protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.952
tolQ
tolQ protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.943
VC_A0576
Heme transport protein HutA; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative.
 
 
 0.936
btuB
Vitamin B12 receptor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
 
 
 
 0.930
VC_A0064
TonB system receptor, putative; Similar to GB:L27149 PID:529727; identified by sequence similarity; putative.
 
 
 0.928
irgA
Iron-regulated outer membrane virulence protein, TonB receptor family; Involved in the initial step of iron uptake by binding ferric vibriobactin, an iron chelatin siderophore that allows V.cholerae to extract iron from the environment; Belongs to the TonB-dependent receptor family.
 
 
 0.923
VC_1547
Biopolymer transport protein ExbB-related protein; Similar to PID:1001734 PID:1001752; identified by sequence similarity; putative.
 
 
 0.918
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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