Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
exbB1TonB system transport protein ExbB1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity). (228 aa)    
Predicted Functional Partners:
exbD1
TonB system transport protein ExbD1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
 
 0.999
tonB
tonB1 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
 
 
 0.993
exbD2
TonB system transport protein ExbD2; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
 
 
 0.979
tolR
tolR membrane protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
 
 
 0.944
VC_A0913
Hemin ABC transporter, periplasmic hemin-binding protein HutB; Similar to GP:2738773; identified by sequence similarity; putative.
  
  
 0.938
VC_1544
tonB2 protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.927
VC_A0914
Hemin ABC transporter, permease protein, putative; Similar to GP:2738774; identified by sequence similarity; putative; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
  
 0.857
hmuV
Hemin ABC transporter, ATP-binding protein HutD; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
     
 0.829
hutX
Conserved hypothetical protein; Binds heme. Heme is transferred to the heme-degrading enzyme HutZ via a specific protein- protein interaction.
 
  
 0.817
VC_A0909
Oxygen-independent coproporphyrinogen III oxidase, putative; Similar to SP:P54304 PID:1303805 GB:AL009126; identified by sequence similarity; putative.
 
   
 0.791
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.