STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A0955Transcriptional regulator, MarR family; Similar to GB:X74409 SP:P42195 PID:396458; identified by sequence similarity; putative. (174 aa)    
Predicted Functional Partners:
murP
PTS system, sucrose-specific IIBC component, putative; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.
     
 0.774
VC_0910
PTS system, trehalose-specific IIBC component; Similar to SP:P36672 GB:U06195 PID:459401 GB:U00096 PID:2367362; identified by sequence similarity; putative.
     
 0.774
VC_0995
PTS system, N-acetylglucosamine-specific IIABC component; Similar to GP:2541900; identified by sequence similarity; putative.
     
 0.774
VC_2013
PTS system, glucose-specific IIBC component; Similar to GB:J02618 SP:P05053 PID:147393 GB:U00096 PID:1651541; identified by sequence similarity; putative.
     
 0.774
VC_A0653
PTS system, sucrose-specific IIBC component; Similar to GB:M76768 SP:P22825 PID:155262; identified by sequence similarity; putative.
     
 0.774
pgi
Glucose-6-phosphate isomerase; Similar to SP:P11537 GB:X15196 PID:396360 PID:42377 GB:U00096; identified by sequence similarity; putative.
     
 0.571
vdcA
GGDEF family protein; Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic- di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation, and reduced motility and virulence.
  
  
 0.558
tkt1
Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.555
tkt2
Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.555
VC_2750
GGDEF family protein; Similar to PID:1653584; identified by sequence similarity; putative.
  
  
 0.532
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.