STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lldDL-lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (378 aa)    
Predicted Functional Partners:
VC_A0985
Oxidoreductase/iron-sulfur cluster-binding protein; Similar to GB:AE000511 PID:2314381; identified by sequence similarity; putative.
  
 0.993
VC_1198
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
 0.987
VC_A0983
L-lactate permease, putative; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.
  
  
 0.949
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.878
VC_A0530
Pyruvate-flavoredoxin oxidoreductase; Similar to GB:U00096 PID:1742250 PID:1742256 PID:1787642; identified by sequence similarity; putative.
    
 0.872
guaB
Inosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.809
prpB
Carboxyphosphonoenolpyruvate phosphonomutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
 
 
 
 0.798
VC_0667
Oxidoreductase Tas, aldo/keto reductase family; Similar to PID:882727 GB:U00096 PID:1789199 PID:2342573; identified by sequence similarity; putative.
  
 
 
 0.794
VC_0392
Aminotransferase, class V; Similar to SP:P31030 PID:164759; identified by sequence similarity; putative.
  
 0.770
phnW
2-aminoethylphosphonate:pyruvate aminotransferase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
  
 0.770
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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