Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VC_A1030
Hypothetical protein; Identified by Glimmer2; putative. (83 aa)
Predicted Functional Partners:
VC_A1029
Glycogen operon protein GlgX; Similar to SP:Q10767 PID:1403478 GB:AL123456; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 13 family.
0.488
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277 Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
VC_A1029
VC_A1030
Glycogen operon protein GlgX; Similar to SP:Q10767 PID:1403478 GB:AL123456; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 13 family.
Hypothetical protein; Identified by Glimmer2; putative.
0.488
VC_A1030
VC_A1029
Hypothetical protein; Identified by Glimmer2; putative.
Glycogen operon protein GlgX; Similar to SP:Q10767 PID:1403478 GB:AL123456; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 13 family.
0.488
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: