Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mtlAPTS system, mannitol-specific IIABC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport. (649 aa)    
Predicted Functional Partners:
mtlD
Mannitol-1-phosphate 5-dehydrogenase; Similar to SP:P09424 GB:X51359 PID:42039 PID:466738 GB:U00096; identified by sequence similarity; putative.
 
 
 0.999
VC_1822
PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative.
 
  
 0.992
VC_1826
PTS system, fructose-specific IIABC component; Similar to GB:AL009126; identified by sequence similarity; putative.
 
  
 0.992
ptsH
Phosphocarrier protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
 
 
 0.989
VC_A0518
PTS system, fructose-specific IIA/FPR component; Similar to PID:619247 SP:P24217 GB:U00096 PID:1736835 PID:1788494; identified by sequence similarity; putative.
 
 
0.986
VC_1824
PTS system, nitrogen regulatory IIA component, putative; Similar to GB:U00096 PID:1788726 PID:1799794; identified by sequence similarity; putative.
  
 
 0.971
VC_A1047
Mannitol operon repressor; Similar to SP:P36563 PID:434583 PID:466739 GB:U00096 PID:1790029; identified by sequence similarity; putative.
 
   
 0.956
VC_1821
PTS system, fructose-specific IIBC component; Similar to SP:P32672 GB:U00006 PID:396296 GB:U00096 PID:1790386; identified by sequence similarity; putative.
 
  
 0.951
VC_A0516
PTS system, fructose-specific IIBC component; Similar to SP:P20966 GB:M23196 PID:405893 PID:450372 GB:U00096; identified by sequence similarity; putative.
 
  
 0.948
VC_A0517
1-phosphofructokinase; Similar to SP:P23539 GB:X53948 PID:405894 PID:41487 GB:U00096; identified by sequence similarity; putative; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.872
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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