Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
VC_A1083Conserved hypothetical protein; Identified by Glimmer2; putative. (235 aa)    
Predicted Functional Partners:
VC_A1082
Hypothetical protein; Identified by Glimmer2; putative.
  
 0.991
VC_2370
Sensory box/GGDEF family protein; Similar to PID:1652133; identified by sequence similarity; putative.
 
 
 0.939
mbaA
c-di-GMP phosphodiesterase A-related protein; Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development, results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels.
 
 
 0.921
VC_A0080
GGDEF family protein; Similar to GP:6759486; identified by sequence similarity; putative.
 
 
 0.917
cdpA
GGDEF family protein; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP). Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V.cholerae, and is proposed to play an important role in the transition from persistence in the environment to survival in the host. CdpA functions as a repressor of biofilm formation but has no effect on colonization of the infant mouse small intestine. Does not possess diguanylate cyclase (DGC) a [...]
 
  
 0.901
VC_2750
GGDEF family protein; Similar to PID:1653584; identified by sequence similarity; putative.
 
  
 0.901
VC_1641
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
  
 0.896
VC_A0536
Conserved hypothetical protein; Identified by Glimmer2; putative.
  
  
 0.895
VC_1934
GGDEF family protein; Similar to GP:3341566; identified by sequence similarity; putative.
 
  
 0.878
VC_A0965
GGDEF family protein; Similar to GB:AE000657; identified by sequence similarity; putative.
  
  
 0.872
Your Current Organism:
Vibrio cholerae
NCBI taxonomy Id: 243277
Other names: V. cholerae O1 biovar El Tor str. N16961, Vibrio cholerae El Tor N16961, Vibrio cholerae O1 biovar El Tor str. N16961, Vibrio cholerae O1 biovar eltor str. N16961, Vibrio cholerae serotype O1 biotype El Tor strain N16961, Vibrio cholerae serotype O1 biotype ElTor strain N16961
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